PRODUCT CATALOG
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Sacubitril-Valsartan
Human API
Route - KSMs and intermediates
- KSMSacubitril calcium1369773-39-6
- KSMValsartan137862-53-4
Characterised impurities
| Impurity | Chemical name | Pharmacopoeia |
|---|---|---|
| "BMP" impurity | (2R,4S)-5-(biphenyl- 4-yl)-4-[(tert- butoxycarbonyl)ami no]-2-methyl pentanoic acid | IHT |
| "SME" impurity (Methyl Ester) Sacubitril Calcium BME Ester | 4-(((2S,4R)-1-([1,1'- biphenyl]-4-yl)-5- methoxy-4-methyl- 5-oxopentan-2- yl)amino)-4- oxobutanoate (2S,4R)-5-(Biphenyl- 4-yl)-4-[(3- Carboxypropionyl)a mino]-2-methyl pentanoic acid ethyl ester calcium salt Ethyl (2R,4S)-5-([1,1'- biphenyl]-4-yl)-4- ((tert- butoxycarbonyl)ami no)-2- methylpentanoate | IHT IHT IHT |
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