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Pyrimethamine
Human API
Characterised impurities
| Impurity | Chemical name | Pharmacopoeia |
|---|---|---|
| DCT EMP | 1-Chloro-4- (dichloromethyl)ben zene Ethyl-2-methyl-3- oxo-pnetanoate | IHT IHT |
| Methyl impurity | 5-(4- chlorophenyl)-6- methylpyrimidine- 2,4-diamine | USDMF /IHT |
| PBC | p-chlorobenzyl cyanide | IHT |
| Ethylene glycol monotosyl ate | Ethylene glycol monotosylate; 2- Hydroxy ethyl-4- toluene sulfonate | IHT |
| Impurity “A” | Phenothiazine | BP/EP/ USDMF |
| Impurity “B” | (2RS)-N,N-Dimethyl- 2-(10H- phenothiazin-10- yl)propan-1-amine hydrochloride | BP/EP/ USDMF ) |
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