Ertugliflozin

Patent status

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Route - KSMs and intermediates

1. KSM3R,4S,5S,6R)-3,4,5-trihydroxy-6- (hydroxymethyl)tetrahydro-2H-pyran-2-one90-80-2
2. KSM4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene461432-23-5
3. KSM(S)-5-oxopyrrolidine-2-carboxylic acid98-79-3
4. Intermediate-01: 3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6- (((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one32384-65-9
5. Intermediate(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4- ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2- methoxytetrahydro-2H-pyran-3,4,5-triol1528636-39-6
6. Intermediate((2R,3R,4S,5R,6S)-6-(4-chloro-3-(4- ethoxybenzyl)phenyl)-6-methoxy-3,4,5- tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2- yl)methanol1210344-57-2
7. Intermediate(2S,3R,4S,5R,6S)-6-(4-chloro-3-(4- ethoxybenzyl)phenyl)-6-methoxy-3,4,5- tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2- carbaldehyde1528636-33-0
8. Intermediate(2S,3S,4S,5R,6S)-6-(4-chloro-3-(4- ethoxybenzyl)phenyl)-3,4,5-trihydroxy-2- (hydroxymethyl)-6-methoxytetrahydro-2H-pyran-2- carbaldehyde32746-79-5
9. Intermediate(2S,3R,4S,5S)-2-(4-chloro-3-(4- ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2- methoxytetrahydro-2H-pyran-3,4,5-triol1528636-39-6
10. Intermediate1S,2S,3S,4R,5S)-5-(4-chloro-3-(4- ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8- dioxabicyclo[3.2.1]octane-2,3,4-triol1210344-57-2
11. Intermediate(1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3- (4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane- 2,3,4-triyl triacetate 20 DULOXETINE HCl1298086-18-6
12. KSM1-Fluoronaphthalene321-38-0
13. KSM2-Acetyl thiophene88-15-3
14. IntermediateS-Dimethyl amino alcohol mandalate salt 21 TRAZODONE HCl108-01-0
15. KSMm-chloro aniline108-42-9
16. KSMN,N-Bis-(2-Chloroethyl)amine Hydrochloride821-48-7
17. KSM1-Bromo-3-Chloro propane109-70-6
18. KSM2-Chloropyridine109-09-1
19. Intermediate2,4-triazolopyridinone6969-71-7
20. Intermediate1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine dihydrochloride 22 FLOUXETINE HCl52605-52-4
21. KSMAcetophenone98-86-2
22. KSM4-chlorobenzotrifluoride98-56-6
23. IntermediateFluoxetine Base 23 BUPROPION HCl54910-89-3
24. KSM3’-Chloropropiophenone936-59-4
25. KSMTertiary butylamine75-64-9
26. IntermediateBromo chloro propiophenone34911-51-8