Edoxaban

Route - KSMs and intermediates

1. KSM2-Amino-5-chloro pyridine1072-98-6
2. KSMEthyl oxalyl chloride4755-77-5
3. KSM5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2- amine17899-48-8
4. KSMTert-butyl((1R,2S,5S)-2-amino-5- (dimethylcarbamoyl)cyclohexyl) carbamate oxalate1210348-34-7
5. IntermediateEthyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride1243308-37-3
6. Intermediate5-methyl-4,5,6,7-tetrahydrothiazolo[5,4- c]pyridine-2-carboxylic acid hydrochloride720720-96-7
7. Intermediatetert-butyl ((1R,2S,5S)-2-(2-((5-chloropyridin-2- yl)amino)-2-oxoacetamido)-5- (dimethylcarbamoyl)cyclohexyl)carbamate480452-36-6
8. IntermediateN1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4- (dimethylcarbamoyl)-2-(5-methyl-4,5,6,7- tetrahydrothiazolo[5,4-c]pyridine-2- carboxamido)cyclohexyl)oxalamide (Edoxaban Base)480449-70-5