PRODUCT CATALOG
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Donepezil
Human API
Characterised impurities
| Impurity | Chemical name | Pharmacopoeia |
|---|---|---|
| TAPS PCP impurity RCP impurity | dimethoxy-2,3- dihydro-1H-indene- 1-one 2,4,5,6-tetraamino pyrimidine suphate (2E)-5,6-dimethoxy- 2-(pyridine-4- ylmethylidine)-3H-1- one 5,6-Dimethoxy-2- (piperidin-4- ylmethylidine)indan- 1-one ; Desbenzyl Donepezil (USP) | IHT IHT IHT |
| Dimer impurity Dibenzyl Impurity Donepezil- N-Oxide Donepezib enzyl (USP- Quatarnar y salt) | 2-(3-(3,4- dimethoxyphenyl)-3- oxopropyl)-5,6- dimethoxy-2,3- dihydro-1H-inden-1- one 4-[(2,3-dihydro-5,6- dimethoxy-1-oxo-1H- inden-2- yl)methyl]-1,1- bis(phenylmethyl)pi peridinum chloride 1-Benzyl-4-[5,6- dimethoxy-1-oxo- 2,3-dihydro-1H- inden-2- yl)methyl]piperidine- oxide (1,1-dibenzyl-4-[(5,6- dimethoxy-1-oxo- 2,3-dihydro-1H- inden-2- yl)methyl]piperidiniu or (1,1-dibenzyl- 4-[(5,6-dimethoxy-1- oxoindan-2- yl)methyl]piperidiniu | IHT IHT USP IHT |
| Impurity “C” | 2-[(1RS)-8-ethyl-1- methyl-1,3,4,9- tetrahydro pyrano[3,4-b]indol- 1-yl]acetic acid (1- methyl Etodolac) | BP/EP/ USP |
| Impurity "D" (8- Isopropyl Etodolac) | [(1RS)-1-Ethyl-8-)1- methylethyl)-1,3,4,9- tetrahydrofuran[3,4- b]indol-1-yl)acetic acid | EP/BP |
| Impurity "G" (1- propyl etodolac) | [(1RS)-8-ethyl-1- propyl)-1,3,4,9- tetrahydrofuran[3,4- b]indol-1-yl]acetic acid | BP/EP |
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