PRODUCT CATALOG
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CITALOPRAM / ESCITALOPRAM
Characterised impurities
| Impurity | Chemical name | Pharmacopoeia |
|---|---|---|
| "C" | cyano-1(3H)- isobenzofuranone oxalate 3-(3- | - |
| Related compound | dimethylaminopropy l)-3-(4- fluorophenyl)-6- cyano-1(3H)- isobenzofuranone oxalate ; (1RS)-1-[3- | USP |
| "C" | (dimethylamino)pro pyl]-1- (fluorophenyl(-3- oxo-1,3-dihydro-2- benzofuran-5- carbonitrile oxalate | - |
| Related compound D (Desmethy | 1-(4-fluorophenyl)-1- methylaminopropyl) -1,3- | USP |
| l Citalopram ) | dihydroisobenzofura n-5-carbonitrile hydrochloride | - |
| Related compound “E” | 1-(3- Dimethylaminoprop yl)-1-(4- fluorophenyl)-1,3- dihydroisobenzo furan-5-carbonitrile- N-oxide 1-(3- Dimethylaminoprop | USP |
| Related compound “E” (N- Oxide) / Impurity "H" | yl)-1-(4- fluorophenyl)-1,3- dihydroisobenzo furan-5-carbonitrile- N-oxide OR Citalopram N-Oxide; 3-[(1RS)-5-cyano-1- (4-fluorophenyl)-1,3- dihydro-2- benzofuran-1-yl]- N,N- | USP/EP /BP |
| Impurity “F” / Related compound “H” | dimethylpropan-1- amine-N-oxide 3-[(1RS)-5-bromo-1- (4-fluorophenyl)-1,3- dihydroisobenzofura n-1-yl]-N,N-dimethyl propan-1-1amine | BP/EP/ USP |
| Citalopram Ketone (Impurity "G") | (Dimethylamino)-1- {1-[3- Dimethylamino)prop yl]-1-(4- fluorophenyl)-1,3- dihydroisobenzofura 5 yl}butan 1 one | USP |
| Impurity "L"/ Desfluoro Citalopram | (1RS)-1-[3- (dimethylamino)pro pyl]-1-phenyl-1,3- dihydro-2- benzofuran-5- carbonitrile oxalate | EP |
| IMPURITY- I | 4~[(1Z)4~ (Dimethylamino)~ 1- (4~f1uorophenyl)but: -yl]-3-(hyd roxymethyl)benzonit rile; Citalopram olefinic; Olefinic Imouritv | EP/BP |
| IMPURITY- J | methylbenzenesulfo monohydrate; toluenesulfonic acid monohydrate Descyano | EP/BP |
| IMPURITY- M | citalopram carboxylic acid; (1RS)-1-[3- (dimethylamino)pro pyl]-1-(4- f1uorophenyl)-1,2- dihydro-2- benzofuran-5- | EP/BP |
| R- Citalopram oxalate | carboxylic acid I-1-[3- (Dimethylamino)pro pyl]-1-(p- fluorophenyl)-5- phthalancarbonitrile oxalate | USP |
| Racemic cyanodiol | [4-)Dimethylamino)- 1-(4-fluorophenyl)-1- hydroxybutyl]-3- (hydroxymethyl)ben zonitrile | IHT |
| N,N- dimethyla mino propyl chloride HCl | N,N-dimethylamino propyl chloride HCl | IHT |
| Cyano diol 2,4- Dibromo- | 4-[4- (Dimethylamino)-1- (4-fluorophenyl)-1- hydroxybutyl]-3- (hydroxymethyl)ben zonitrile 2,4-Dibromo-1- | IHT |
| 1- fluorobenz ene Fluoroben zene Oxalate salt of Ene imp. of | fluorobenzene 1-Fluorobenzene 5-Cyano-2-(4- (dimethylamino)-1- (4-fluorophenyl)but- | IHT IHT IHT |
| monoacet ylcyanoest er 1-Bromo- 3- Chloropro pane | 1-en-1-yl)benzyl acetate oxalate 1-Bromo-3- Chloropropane | IHT |
| Olefin impurity of racemic cyanodiol | 4-[4- (dimethylamino)-1- (4-fluorophenyl)1- buten-1-yl]-3- (hydroxymethyl)- benzonitrile | IHT |
| 5- Carbamoyl phthalide P-Toluic acid | 1,2-Dihydro-1-oxo-5- isobenzofuran carboxamide 4-Methyl benzoic acid | IHT IHT |
| Impurity E, Racemic cyanodiol hydrobro mide | (4RS)-4-[4-cyano-2- (hydroxymethyl)phe nyl]-4-(4- fluorophenyl)-4- hydroxy-N,N- dimethylbutan-1- aminium bromide | EP/IHT |
| “Acrylate” | Diethyl {[(3- chlorophenyl)amino] methylidene} propane dioate | - |
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