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CETIRIZINE HYDROCHLO RIDE
Characterised impurities
| Impurity | Chemical name | Pharmacopoeia |
|---|---|---|
| Impurity “C” | (RS)-2-[2-[4-(2- chlorophenyl)phenyl methyl]-piperazin-1- yl]ethoxy]acetic acid | BP/EP |
| Impurity “D” (Cetirizine Dimer) | 1,4-bis[(4- chlorophenyl)phenyl methyl] piperazine | EP |
| Impurity “E” | (RS)-2-[2-[2-[4-[(4- chlorophenyl)phenyl methyl]piperazin-1- yl]ethoxy]ethoxy]ace tic acid | BP/EP |
| Impurity “F” Deschloro cetirizine | [2-[4- (diphenylmethyl)pip erazin-1- yl]ethoxy]acetic acid | BP/EP/ USP |
| Impurity "G"/Relate d Compound "G" | 2-[4-[(RS)-(4- chlorophenyl)phenyl methyl]piperazin-1- yl]ethanol | BP/EP |
| 3-Chloro Cetirizine | 2-[2-[4-[(3- Chlorophenyl)phenyl methyl]-1- piperazinyl] ethoxy]acetic acid | USP |
| Piperazine | 1,4- Diazacyclohexane | IHT |
| 4-CBH | 4-Chlorobenzhydrol | IHT/US DMF |
| “PCBHP” (Impurity "A") | 1-[ 4-( chloro phenyl)phenyl methyl ]-piperzine | IHT |
| PCBH Dimer | Bis[(1-(4- chlorophenyl)-1- phenyl)methyl ether | IHT |
| 4- chloroben zo- phenone | (4- chlorophenyl)phenyl methanone | USP |
| “Methyl ester” N-Oxide | Methyl 2-(2-{4-[(4- Chloro-phenyl) phenylmethyl] piperazin-1-yl} ethoxy) acetate 2-(2-{4-[(4- chlorophenyl) (phenyl)methyl]pipe razine-1-yl}acetic acid N-Oxide | USDMF USP |
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