PRODUCT CATALOG
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Bisoprolol Fumarate
Human API
Characterised impurities
| Impurity | Chemical name | Pharmacopoeia |
|---|---|---|
| Impurity A | (2RS)-1-(4- hydroxymethyl- phenoxy)-3- isopropyl aminopropan-2-ol | (EP) |
| Impurity L | 4-[(2RS)-2-hydroxy- (isopropylamino)pro pyl] oxy]benzaldehyde | (EP) |
| Impurity N | 1-(4-((2- ethoxyethoxy)methy l)phenoxy)-3- isopropyl amino)propan-2-ol hydrochloride | (EP) |
| Impurity “S” | hydroxybenzaldehyd | BP/EP |
| Impurity T | 4-((3-isopropyl-2- oxooxazolidin-5- yl)methoxy)benzalde hyde | (EP) |
| Impurity U Chlorhydri | 5-((4- (hydroxymethyl)phe noxy)methyl)-3- isopropyloxazolidine -2-one 1-chloro-3-(4-{[2- (propan-2- yloxy)ethoxy] | (EP) IHT |
| ne Epoxide compound | methyl} phenoxy)propan-2-ol 2-({4-[(2-isopropoxy ethoxy)methyl]phen oxy}methyl oxirane | IHT |
| Isopropox y ester | 2-Isopropoxyethyl-4- hydroxybenzoate | IHT |
| Epoxide ester | 2-Isopropoxyethyl-4- (2,3- Epoxypropoxy)benzo ate | IHT |
| Impurity “K” 4- Hydroxybe | 2-isopropoxyethyl-4- [[(2RS)-2-hydroxy-3- (isopropylamino)pro pyl]oxy]benzoate 4-hydroxy | IHT IHT |
| nzyl alcohol Impurity "Q" | methlphenol (2RS)-1- (isopropylamino)-3- [4-(2- methoxyethoxy)met hyl] phenoxypropan- 2-ol fumarate | EP |
| Impurity "R" N-Formyl compound | (2RS)-1- (isopropylamino)-3- methylphenoxy)prop an-2-ol fumarate N-(2-Hydroxy-3-(4- ((2- isopropoxyethoxy)m ethyl)phenoxy) propyl)-N- isopropylformamide | EP IHT |
| Impurity “A” | {5-[(E)-(4- Carboxyphenyl)diaze nyl]-2- hydroxybenzoic acid} | IHT |
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